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Updated: Jul 28, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
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淋巴细胞与单细胞的比作为预后和潜在的瘤微环境指标在先进的软组织肉瘤治疗第一线多克索鲁比治疗治疗

Sho Watanabe1,2, Tatsunori Shimoi3, Tadaaki Nishikawa1

  • 1Department of Medical Oncology, National Cancer Center Hospital, 1-1, Tsukiji 5, Chuo-ku, Tokyo, 104-0045, Japan.

Scientific reports
|July 3, 2023
PubMed
概括

低淋巴细胞与单细胞比率 (LMR) 预测在接受多克索鲁比治疗的晚期软组织肉瘤 (STS) 患者的生存率不佳. 在瘤微环境 (TME) 中,LMR可能反映出抗瘤免疫力.

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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...