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Updated: Jul 24, 2025

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发现了VH域的发现,这些VH域可以全osterically抑制ENPP1的ENPP1

Paige E Solomon1, Colton J Bracken1,2, Jacqueline A Carozza3

  • 1Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA.

Nature chemical biology
|July 3, 2023
PubMed
概括

研究人员开发了新的生物抑制剂,向ectodomain酸酶/化-1 (ENPP1),这是一个先天免疫检查点. 这些抑制剂通过阻断ENPP1对癌症免疫治疗具有前景.

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