细菌在癌症启动,促进和进展中的作用
Geniver El Tekle1,2,3, Wendy S Garrett4,5,6,7,8
1Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Nature reviews. Cancer
|July 3, 2023
概括
人类微生物组影响癌症的发展和进展. 了解这些微生物的作用为癌症预防,诊断和个性化治疗提供了新的途径.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 癌症是由遗传突变引起的,但环境因素,如微生物群,显著影响瘤细胞行为和瘤微环境.
- 肠道微生物组失调是癌症的公认标志,但特定的微生物在瘤发生和免疫调节中的作用仍在被阐明.
- 超过二十年的研究突出了微生物群对健康和疾病的影响,促使人们对以微生物群为中心的健康策略进行调查.
研究的目的:
- 审查不断发展的关于微生物群如何影响癌症发病,促进和进展的理解.
- 探索细菌在各种癌症中的特定作用,包括胃肠道,肺,乳腺和前列腺恶性瘤.
- 讨论利用基于细菌的策略用于个性化癌症预防,诊断和治疗的潜力和挑战.
主要方法:
- 关于人类微生物组和癌症的科学研究的文献综述.
- 分析微生物群影响癌症发展的机制.
- 探索细菌在特定癌症类型和治疗策略中的作用.
主要成果:
- 微生物群通过各种机制显著影响癌症的启动,促进和进展.
- 特定的细菌已与胃肠道,肺,乳腺和前列腺癌有关.
- 准或利用微生物组为个性化癌症护理提供了有希望,但具有挑战性的途径.
结论:
- 微生物群在癌症的发展和进展中起着至关重要的作用.
- 对微生物机制的进一步研究对于开发有效的癌症干预措施至关重要.
- 利用微生物组有可能实现个性化癌症预防,诊断和治疗,但需要仔细考虑局限性.
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