尿中的2-基南与当前的喘有关:来自NHANES 2007-2012年的证据
Lingyi Lu1, Tingfeng Mao1, Rui Xu1
1Xuhui District Center for Disease Control and Prevention, 200237, Shanghai, China.
概括
尿液中的多环芳化合物 (PAH) 代谢物2-基 (2-OHPHE) 与当前的喘有很强的联系. 需要进一步的研究来证实PAH暴露与喘风险之间的关系.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 多环芳 (PAH) 是与各种健康问题相关的环境污染物.
- 尿中的单氧PAH代谢物 (OHPAH) 作为PAH暴露的生物标志物.
- 喘是一种常见的慢性呼吸道疾病,具有复杂的病因.
研究的目的:
- 调查尿液OHPAH水平与美国成年人当前喘之间的关联.
- 为了确定可能与喘风险增加相关的特定OHPAHs.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (2007-2012) 中对3804名成年人的横截面分析.
- 使用多变量逻辑回归,贝叶斯内核机器回归 (BKMR) 和定量g计算 (qgcomp) 来分析数据.
- 在统计模型中控制潜在的混因素.
主要成果:
- 尿中的2-基 (2-OHPHE) 显示在男性和女性吸烟者中与当前喘有显著的关联.
- 量子g计算确定了2-OHPHE,1-氨酸 (1-OHNAP) 和2-氨酸 (2-OHNAP) 作为喘风险的主要积极贡献者.
- 特定的OHPAHs,包括9-化 (9-OHFLU) 和2-化 (2-OHFLU),也与吸烟女性的喘风险有关.
结论:
- 尿路2-OHPHE与当前的喘有很强的关联,特别是在吸烟者中.
- 这些发现强调了特定PAH代谢物的潜在作用在喘发育.
- 建议进行长度研究,以阐明PAH暴露与喘风险之间的因果关系.
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