对新诊断的多发性骨髓瘤进行响应适应疗法
Winnie Z Y Teo1,2, Ian Y E Ong3, Jason W Y Tong4
1Department of Haematology-Oncology, National University Cancer Science Institute of Singapore (NCIS), National University Health System, Singapore, Singapore.
Current hematologic malignancy reports
|July 3, 2023
概括
针对多发性骨髓瘤 (MM) 的响应适应疗法显示出有前途. 整合最小残留疾病 (MRD) 监测可以个性化治疗,提高疗效和降低成本.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 新型药物改善了多发性骨髓瘤 (MM) 的结果.
- 治疗决策因反应异质性,多种选择和成本而变得复杂.
- 响应适应疗法在MM中未得到充分利用,尽管在其他血液癌症中取得了成功.
研究的目的:
- 审查MM中目前适应应答的治疗策略.
- 讨论这些策略在治疗算法中的未来实施和改进.
主要方法:
- 对MM的响应适应治疗现有文献的综述.
- 分析最小残留疾病 (MRD) 在治疗适应中的作用.
- 考虑新的响应评估技术,包括敏感的偏蛋白量化和成像.
主要成果:
- 仅靠早期反应标准可能无法预测长期结果.
- 最小残留疾病 (MRD) 是一个重要的预后因素,使得MRD适应的策略.
- 先进的技术为临床试验提供了敏感和整体的反应评估.
结论:
- 响应适应的算法可以个性化MM治疗,最大限度地提高疗效,最大限度地降低毒性/成本.
- 标准化MRD方法对于未来的试验至关重要.
- 纳入成像和确定MRD阳性患者的最佳管理是关键的研究问题.
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