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Updated: Jul 24, 2025

Characterization of Membrane Transporters by Heterologous Expression in E. coli and Production of Membrane Vesicles
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Published on: December 31, 2019

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人类GABA载体GAT1的基质识别和运输的分子基础

Angqi Zhu1, Junhao Huang1, Fang Kong1

  • 1State Key Laboratory of Membrane Biology, Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.

Nature structural & molecular biology
|July 3, 2023
PubMed
概括

研究人员使用冷EM可视化了人类的γ-氨基黄油酸载体1 (GAT1). 结构揭示了GAT1如何结合和运输神经递质GABA,以及 tiagabine 等药物如何抑制它.

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