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Updated: Jul 24, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
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细胞衰老的空间绘制:新出现的挑战和机遇

Aditi U Gurkar1, Akos A Gerencser2, Ana L Mora3

  • 1Aging Institute, University of Pittsburgh School of Medicine/UPMC and Division of Pulmonary, Allergy and Critical Care Medicine, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Nature aging
|July 3, 2023
PubMed
概括

绘制衰老细胞的地图,这是衰老和疾病的关键,由于标记物稀缺性和异质性,这是一个挑战. 新的空间成像方法对于创建这些细胞的全面地图库至关重要.

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Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
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