夜班工作与NAFLD之间的关联:对281,280名英国生物银行参与者的前性分析
Hangkai Huang1, Zhening Liu1, Jiarong Xie1,2
1Department of Gastroenterology, Zhejiang Provincial Clinical Research Center for Digestive Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine. No, 79 Qingchun Road, Hangzhou, 310003, China.
BMC public health
|July 3, 2023
概括
夜班工作增加了患非酒精性脂肪肝疾病 (NAFLD) 的风险. 这种关联在一项大型英国生物银行研究中观察到,突出显示了轮班工人的潜在健康影响.
科学领域:
- 流行病学 流行病学
- 职业健康 职业健康 职业健康
- 肝病学 肝病学是一种肝病学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的公共卫生问题.
- 职业因素,如夜班工作对NAFLD风险的影响尚未完全理解.
研究的目的:
- 调查夜班工作与非酒精性脂肪性肝病 (NAFLD) 发生率之间的联系.
主要方法:
- 对281,280名英国生物银行参与者的前性分析.
- 使用了考克斯的比例危险模型和多基因风险评分分析.
- 随访时间为12.1年,确定了2,555例NAFLD病例.
主要成果:
- 一些或通常/永久夜班的工人患NAFLD的可能性分别高出1.12和1.27倍.
- 更长的时间,更高的频率和更多连续的夜班与NAFLD风险增加有关.
- 遗传倾向并没有改变夜班工作和NAFLD之间的关联.
结论:
- 夜班工作与发生非酒精性脂肪性肝病 (NAFLD) 的风险增加有关.
- 研究结果表明,职业时间表可能在NAFLD发展中发挥作用.
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