CBIT + TMS试验:为一项两期随机对照试验的研究协议,测试神经调节以增强患有慢性的青少年的行为治疗
Christine Conelea1, Deanna J Greene2, Jennifer Alexander3
1Department of Psychiatry and Behavioral Sciences, Masonic Institute for the Developing Brain, University of Minnesota, 2025 E. River Parkway, Minneapolis, MN, 55414, USA. cconelea@umn.edu.
Trials
|July 3, 2023
概括
这项研究调查了跨磁性刺激 (TMS) 是否可以增强对症的综合行为干预 (CBIT). 研究人员的目标是通过准补充运动区域 (SMA) 来改善滴滴控制.
科学领域:
- 神经科学是一个神经科学.
- 临床心理学 临床心理学
- 神经调节是一种神经调节.
背景情况:
- 综合性行为干预治疗 (CBIT) 是治疗的第一线治疗方法,但其有效性仅限于大约一半的患者.
- 补充运动区域 (SMA) 在运动抑制中起着至关重要的作用,并与的表达有关.
- 使用跨磁刺激 (TMS) 针对性调节SMA可能会提高CBIT的有效性.
研究的目的:
- 测试增强CBIT与针对SMA的TMS是否可以改善慢性的青少年的控制能力.
- 调查SMA介导电路的TMS调制是否可以提高CBIT的疗效.
- 探索潜在治疗效果背后的神经和行为机制.
主要方法:
- 这是一项两期随机对照试验 (NCT04578912),涉及12至21岁的青少年,患有慢性.
- 第1阶段比较了两种重复性TMS (rTMS) 策略 (1 Hz rTMS与连续的达爆发刺激 (cTBS)) 与假刺激.
- 第二阶段将将最佳的rTMS疗法与假药进行比较,评估神经位参与和临床结果.
主要成果:
- 这一早期试验旨在确定增强CBIT的最佳TMS疗法.
- 该研究将提供关于TMS作为Tic障碍的附加治疗的可行性和潜在疗效的数据.
- 结果将告知SMA电路中的神经变化与提升控制能力之间的联系.
结论:
- 这项试验是第一个在儿科群体中评估TMS增强行为治疗的试验.
- 调查结果将提供对TMS的见解,作为一种可行的策略,以提高对TIC障碍的CBIT疗效.
- 这项研究旨在阐明驱动治疗反应的神经和行为机制.
相关概念视频
Modeling in Therapy
127
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
127
Operant Conditioning Intervention
88
Operant conditioning serves as a foundational principle in therapeutic interventions aimed at modifying maladaptive behaviors. Central to this approach is the notion that behaviors, both adaptive and maladaptive, are learned through reinforcement. By analyzing the environmental factors that reinforce problematic behaviors, clinicians can design interventions to weaken these reinforcements and replace maladaptive behaviors with healthier alternatives.
In operant conditioning, behaviors that are...
In operant conditioning, behaviors that are...
88
Behavior Therapy
82
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
82
Behavior Modification
202
Behavioral approaches have often been criticized for ignoring mental processes and focusing solely on observable behavior. However, these approaches provide an optimistic perspective for individuals seeking to change their behaviors. Rather than concentrating on intrinsic personality traits, behavioral approaches suggest that even longstanding habits can be modified by changing the reward contingencies that maintain them.
A real-world application of operant conditioning principles is applied...
A real-world application of operant conditioning principles is applied...
202


