精神分裂症的进展轨迹跨越症状,基因和大脑
Sisi Jiang1,2, Huan Huang1, Jingyu Zhou1
1The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 611731, People's Republic of China.
BMC medicine
|July 3, 2023
概括
这项研究揭示了精神分裂症中独特的功能性大脑轨迹,随着疾病的进展,从主要区域转移到更高阶区域. 这些模式与遗传因素有关,提供了新的干预目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 精神分裂症呈现复杂的症状和不清楚的病理机制.
- 之前的研究集中在结构变化上,使得疾病进展过程中的功能轨迹不明朗.
- 这项研究调查了精神分裂症诊断后的渐进性功能性大脑功能障碍模式.
研究的目的:
- 探索精神分裂症中大脑功能障碍的渐进轨迹.
- 将功能神经成像发现与临床症状和遗传数据联系起来.
- 根据疾病阶段来确定潜在的治疗点.
主要方法:
- 利用了86名精神分裂症患者和120名健康对照的发现数据集.
- 使用休息状态功能性MRI数据的持续滑动动态分析来追踪功能轨迹.
- 与临床症状和基因表达数据相关的神经影像发现;在复制队列中得到验证.
主要成果:
- 确定了五个特定阶段的表型,具有不同的症状轨迹 (例如,阳性主导,负向上的).
- 揭示了从初级/亚皮层区域到更高层次皮层的渐进性功能障碍,与感官门和兴奋抑制平衡有关.
- 观察到与行为相关的神经成像特征的转变,从疾病阶段的初级到更高级区域;涉及神经发育,神经退行和突触因素.
结论:
- 精神分裂症中的渐进性症状和功能神经成像表型与遗传因素有关.
- 功能性轨迹提供了一个动态的视图,补充了结构性发现.
- 已确定的轨迹为精神分裂症的特定阶段干预提供了潜在的目标.
更多相关视频
相关概念视频
Biological Causes of Schizophrenia
103
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
103
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
756
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
756
Psychological and Sociocultural Causes of Schizophrenia
145
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
145
Schizophrenia
146
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
146
Positive Symptoms of Schizophrenia: Hallucinations and Delusions
177
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
177
Human Genetics
619
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
619


