心室全球功能指数与儿科肺高血压的临床结果有关
Hieu T Ta1,2, Paul J Critser1,2, Michal Schäfer3
1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
概括
全球心室功能指数 (GFI) 显示了儿科肺高血压 (PH) 的预后价值. 这种心脏磁共振成像 (CMR) 度量预测了不良结果,在PH患者中比传统措施具有优势.
科学领域:
- 心脏病学 心脏病学
- 儿科医学 儿科医学
- 医疗成像医学成像
背景情况:
- 右心室 (RV) 度量对于肺高血压 (PH) 的预后至关重要.
- 来自心磁共振成像 (CMR) 的全球心室功能指数 (GFI) 显示了成人不良结果的预测价值.
- GFI以前没有在儿科PH群体中进行评估.
研究的目的:
- 评估使用GFI作为儿童PH患者复合不良结果 (CAO) 预测器的可行性.
- 将GFI的预测性能与传统的CMR衍生的指标进行比较.
主要方法:
- 在2005年1月至2021年6月期间接受CMR的儿科PH患者的回顾性图表审查.
- 计算GFI (中风体积除以平均心室腔和心肌体积).
- 将CAO定义为死亡,肺移植,Potts分离器或肠道前列腺素启动;使用Cox比例危险回归进行分析.
主要成果:
- 该研究包括89名儿科PH患者;24%的患者经历了CAO.
- 患有CAO的患者具有显著更高的索引RV体积和质量,但更低的射出分数 (EF) 和GFI.
- 较低的RV GFI (<43%) 与无事件生存率降低和CAO风险增加有关.
- 多变量模型显示,与心室体积,质量或EF相比,GFI改善了CAO预测.
结论:
- RV GFI是儿科PH中CAO的显著预测因素.
- 与传统的CMR标志物如RV EF相比,GFI提供了增强的预后价值.
- GFI是由随时可用的CMR数据衍生出来的,不需要额外的后处理,使其成为潜在的有价值的临床工具.
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