在手术前患者静脉注射铁前和后进行心肺运动检测:一项前性临床研究
James O M Plumb1,2,3,4, James M Otto5,6,7,8, Shriya B Kumar5
1Perioperative and Critical Care Theme, NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust/University of Southampton, Southampton, UK. j.plumb@soton.ac.uk.
Perioperative medicine (London, England)
|July 3, 2023
概括
静脉注射铁改善了手术前贫血患者的血红蛋白和运动能力. 这种治疗增加了总血红蛋白质量,峰值氧气消耗和峰值工作速度,这表明对手术结果的潜在好处.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 运动医学 运动医学
背景情况:
- 贫血会影响身体表现和术后结果.
- 缺铁性贫血通常在选择性手术前用静脉注射铁治疗.
- 这项研究研究了运动能力,贫血和总血红蛋白质量对IV铁的反应.
研究的目的:
- 探索运动能力,贫血和总血红蛋白质量之间的关系.
- 评估接受选择性手术的贫血患者对静脉注射铁的反应.
主要方法:
- 一项前性临床研究,涉及血红蛋白<130 g/L和缺铁/消耗铁的患者.
- 心肺运动测试 (CPET) 和血红蛋白总质量 (tHb-质量) 测量在静脉注射铁 (费里克脱脂糖) 之前和之后.
- 血液学和CPET变量的比较分析治疗前和后.
主要成果:
- 20名患者完成了该研究,6名患者退出了该研究.
- 输血铁增加了血红蛋白度 ([Hb]) 从109±14增加到116±12g/L (p<0.0001).
- tHb质量从497±134增加到546±139g (p<0.0001),峰值氧气消耗 (VO2峰值) 增加 (p=0.02),峰值工作速度增加 (p=0.02).
结论:
- 在贫血患者中,手术前输入铁增加了[Hb],tHb质量,峰值氧气消耗和峰值工作速度.
- 需要进行进一步的研究,以确定这些改善是否会减少外科手术后的发病率.
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