基于脆弱性指数和反向脆弱性指数,分析了2000年至2020年间对尾进行的随机对照试验
Carlos Placer-Galán1, Jose María Enriquez-Navascués1, Ane Etxart Lopetegui1
1Colorectal Unit, Department of Surgery, Hospital Universitario Donostia, San Sebastian, Spain.
概括
关于管管管理的随机对照试验往往缺乏稳定性. 许多研究显示的结果很脆弱,这表明该领域的研究结果可能不可靠.
科学领域:
- 结肠直肠外科手术是什么意思
- 临床试验方法论 临床试验方法论
- 基于证据的医学是基于证据的医学.
背景情况:
- 随机对照试验 (RCT) 对于基于证据的治疗决定至关重要.
- 随机试验试验结果的可靠性可能受到样本大小和患者随访等因素的影响.
- 评估已发表的RCT的可靠性对于临床实践至关重要.
研究的目的:
- 评估随机对照试验 (RCT) 关于管管管理的可靠性.
- 应用脆弱性指数 (FI),反向脆弱性指数 (RFI) 和相应的脆弱性系数来评估研究结果.
主要方法:
- 在主要数据库 (MEDLINE,EMBASE,Cochrane,Web of Science) 中按照PRISMA指南进行了系统的文献搜索.
- 包括专注于管管管理的RCT,发表于2000-2022年之间,结果分歧和1:1分配.
- 使用2x2应急表计算FI和RFI,定义基于FI/RFI值相对于样本大小和丢失后跟踪率的脆弱性.
主要成果:
- 在36个纳入RCT (3223名患者) 中,有19个呈阳性,17个呈阴性. 中位数FI为2,中位数RFI为5.
- 观察到FI和p值/事件数,以及RFI和p值/样本大小/治疗/伤害所需数量之间存在显著的相关性.
- 发现很大一部分研究是脆弱的:63.2%的积极RCT和35.3%的负面RCT.
结论:
- 在管管管理方面发表的RCT表明他们的研究结果缺乏稳定性.
- 结果的脆弱性表明,从这些研究中得出的结论可能不可靠.
- 对于管治疗的RCT,需要进一步的方法严格,以确保可靠的临床证据.
相关概念视频
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