在接受血造干细胞移植的患者口腔粘膜炎
Murad Ali, Asghar Ali Kerio1, Tariq Azam Khattak
1Department of Clinical Hematology, Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan.
概括
造血干细胞移植 (HSCT) 可以导致口腔粘膜炎,这是一个痛苦的并发症. 骨髓损伤性调节,预防性甲状腺和先前的脊辐射显著增加了它的发生和严重程度.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 移植医学 移植医学 移植医学
背景情况:
- 口腔粘膜炎 (OM) 是血液造血干细胞移植 (HSCT) 后的常见和严重并发症.
- 了解风险因素对于管理OM和改善移植后患者的结果至关重要.
研究的目的:
- 确定影响HSCT患者口腔粘膜炎的频率和严重性的因素.
- 评估特定治疗和患者特征与OM发展之间的关联.
主要方法:
- 在武装部队骨髓移植中心进行了一项描述性研究.
- 72名接受全源性HSCT的患者使用世卫组织尺度对OM进行了分析.
- 评估了风险因素,包括年龄,性别,条件化疗,用于GVHD预防的甲醇 (MTX),以及先前的辐射.
主要成果:
- OM发生在79.3%的15岁以下患者和74.4%的15岁以上患者中.
- 在OM和骨髓缩条件 (85%),预防性MTX (91%) 和先前脊辐射 (100%) 之间发现了显著的关联.
- 与自动HSCT相比,异构HSCT的OM严重程度更高,所有患者都需要止痛.
结论:
- 口腔粘膜炎是一种常见的,使人虚弱的HSCT并发症,需要显著的疼痛管理.
- 骨髓缩条件,预防性MTX和先前的CSI是HSCT患者OM发展的关键风险因素.
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