在细胞癌患者的尼沃卢马布诱导的免疫相关的中性
1Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey.
概括
免疫检查点抑制剂 (ICI) 可以导致免疫相关的中性质衰竭 (irN). 本病例报告详细介绍了接受尼沃卢马布治疗的转移性清晰细胞细胞癌患者的irN,强调了皮质类固醇的使用和停止治疗后的疾病稳定性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 改善了固体瘤的预后.
- ICI可以引起与免疫相关的不良事件 (irAEs).
- 免疫相关的中性质 (irN) 是一种罕见但显著的irAE.
研究的目的:
- 在患有转移性清细胞癌 (ccRCC) 的患者中报告irN病例.
- 描述尼沃卢马布诱导的IRN的临床过程,管理和结果.
- 在ICI治疗的背景下讨论irN的含义.
主要方法:
- 一个47岁男性的病例介绍,他患有转移性ccRCC,接受了nivolumab治疗.
- 详细的临床评估,包括实验室测试和评估中性衰竭的其他原因.
- 监测对皮质类固醇的中性质衰竭反应和停止服用尼沃卢马布.
主要成果:
- 在18个月的尼沃卢马布单独治疗期间,出现严重的中性质衰竭.
- 相关发现包括腹腔和阳性抗中性粒细胞抗体.
- 用皮质类固醇缓解了中性,但在重新引入尼沃卢马布后复发.
- 在停用尼沃卢马布后的9个月随访期间,没有观察到疾病进展.
结论:
- 与尼沃卢马布治疗转移性ccRCC相关的免疫相关的中性质减退不常见.
- 人们对irN的病理生理学仍然不完全了解.
- 皮质类固醇是IRN的主要治疗方法.
- 随着ICI使用的增加,瘤学家将更频繁地面对IRN.
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