慢性骨髓性白血病,氨酸激酶抑制剂和心血管系统的使用
1Department of Hematology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. umitmalkan@hotmail.com.
概括
慢性髓性白血病 (CML) 患者的心血管健康至关重要,这些患者接受氨酸激酶抑制剂 (TKIs). 管理TKI心脏毒性对于实现治愈和改善长期生活质量至关重要.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性髓性白血病 (CML) 患者的延长生存期需要专注于心血管健康.
- 在CML治疗中使用的第二代和第三代氨酸激酶抑制剂 (TKI) 与心脏毒性有关.
- 诸如心肌梗塞,中风和高血压等心血管事件是令人担忧的重大问题.
研究的目的:
- 在慢性髓性白血病 (CML) 患者中,审查氨酸激酶抑制剂 (TKIs) 和心血管系统之间的相互作用.
- 阐明TKIs对心血管系统的影响,以支持治愈性CML治疗目标.
- 突出心血管健康在实现CML患者正常生存和生活质量的重要性.
主要方法:
- 通过使用MEDLINE,EMBASE和Google Scholar进行文献搜索,直到2022年8月.
- 搜索术语包括"慢性髓性白血病"",铁氨酸激酶抑制剂"和"心血管系统".
- 包括的研究是用英语进行的,涉及人类受试者.
主要成果:
- 量身定制的TKI治疗需要考虑CML风险,患者年龄,并发症和TKI非标效应.
- 无治疗生存和最大限度地减少TKI不良事件是关键,但最佳剂量和持续时间仍在争论中.
- 心血管并发症显著影响CML患者的结果,需要仔细评估和考虑在高风险人群中停止治疗或选择HSCT等替代方案.
结论:
- 心血管疾病是实现CML治愈与正常生存和生活质量的主要障碍.
- 将心血管视角纳入CML治疗决策至关重要.
- 仔细的患者评估和与TKI相关的心血管风险的管理对于最佳的CML患者护理至关重要.
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