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再组合原蛋白生物合成中的绿色生物制造:各种表达系统中的趋势和选择

Zilong Zhao^1,2,3, Jianjun Deng^1,2,3, Daidi Fan^1,2,3

¹Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Xi'an 710069, Shaanxi, China. fandaidi@nwu.edu.cn.

Biomaterials science

|July 4, 2023

概括

再组合原蛋白的生产正在通过合成生物学进步,克服了产量和免疫性方面的挑战. 本综述探讨了开发市场竞争力的原蛋白的各种表达系统.

科学领域:

生物技术是生物技术.
生物材料科学生物材料科学
合成生物学合成生物学

背景情况:

原蛋白传统上来源于动物,在生物医学,化品和食品工业中至关重要.
越来越多的需求和提取的复杂性推动了对重组原蛋白生产的兴趣.
再组合原蛋白的绿色生物制造是一个关键的研究领域.

研究的目的:

审查过去二十年来复合原生物生产的进展.
分析不同生物表达系统的原合成.
讨论市场竞争力的重组原体的挑战和未来方向.

主要方法:

对复合原蛋白生物生产的研究进行审查.
分析各种表达系统,包括 prokaryotic,酵母,植物,昆虫和哺乳动物细胞.
讨论免疫性,产量和降解等挑战.

主要成果:

再组合原生物生产已经取得了重大进展.
多种表达系统正在被用于原蛋白合成.
一些重组原蛋白已经商业化.

结论:

合成生物学提供了回组合原体的优化生产和生物活性.
克服生物合成挑战对于市场竞争力至关重要.
未来的趋势集中在开发高效和可扩展的重组原蛋白生产方法.

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