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在患有先天性心脏缺陷的个体中,从出生到成年期的存活率:CH STRONG
Karrie F Downing1, Wendy N Nembhard2, Charles E Rose1
1National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA (K.F.D., C.E.R., M.E.O., S.L.F.).
Circulation
|July 4, 2023
概括
在1980年至1997年间出生于美国的先天性心脏缺陷患者中,每10个就有8个活到35岁. 根据心血管疾病的严重程度,其他异常的存在,出生体重和母亲的种族/种族而异.
科学领域:
- 心脏病学
- 公共卫生
- 儿童医学
背景情况:
- 对于美国患有先天性心脏缺陷 (CHD) 的人群,长期存活的数据有限.
- 了解生存模式和相关因素对于改善这一群体的护理和结果至关重要.
研究的目的:
- 评估从出生到35岁的慢性病患者的长期生存模式.
- 确定与心血管疾病患者的存活率和死亡率相关的因素.
主要方法:
- 使用了美国3个出生缺陷监测系统的数据,
- 将心血管疾病数据与2015年的死亡记录联系起来,以确定生存状况和死亡年份.
- 使用卡普兰-梅尔生存曲线,调整后的风险比率 (aRR) 和Cox比例危险比率 (aHR) 来分析生存和死亡因素.
主要成果:
- 患有心血管疾病的患者的35岁总生存率为81. 4%.
- 严重的心脏病,遗传综合征,非心脏异常,低出生体重和特定的母亲种族/种族与增加的婴儿死亡率和减少的长期存活率有关.
- 与一般人群相比,患有心脏病的个体的婴儿和幼儿死亡率较高,但在没有心脏异常或晚年患有较轻心脏病的人群中,死亡率接近一般人群的水平.
结论:
- 在1980年至1997年间出生的患有冠状动脉疾病的个体中,大约有80%的人活到年轻 (35岁).
- 生存差异与心血管疾病的严重程度,同时出现的异常,出生体重和母亲的种族/种族有关.
- 在没有心脏异常的个体中,1至35岁之间的死亡率与一般人群相比,突出显示了同时出现的疾病对长期结果的影响.
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