通过教育成就和中风,两个不良的童年经历和晚年认知功能之间的时间延迟关联通过教育成就和中风
A Zarina Kraal1,2,3, Afsara B Zaheed4,5, Anna Krasnova6
1Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
概括
儿童暴露于父母的药物滥用或身体虐待与老年成年人的认知功能较差有关. 这些不利的童年经历 (ACE) 通过包括教育成就和中风在内的途径影响认知.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 不利的童年经历 (ACE) 与负面的健康结果有关.
- 老年人的认知健康可以受到早期生活经历的影响.
研究的目的:
- 研究两种ACE与老年人认知功能之间的特定,持久的关联.
- 探索调解途径,包括教育成就和中风,将ACE与认知衰老联系起来.
主要方法:
- 在健康和退休研究中利用了来自3304名老年人的数据.
- 以后回顾评估了父母的药物滥用和父母的身体虐待.
- 采用全面的神经心理电池和结构方程建模来分析认知领域和调解器.
主要成果:
- 儿童时期父母滥用药物与所有领域的认知功能恶化有关,部分是由教育和中风调解的.
- 儿童时期父母的身体虐待与通过中风导致较差的认知结果有关,独立于教育.
结论:
- ACE与认知衰老有广泛而持久的间接关联.
- 教育成就和中风是ACEs认知影响的关键调解途径.
- 进一步的研究应该探索干预策略的其他ACE,机制和调节者.
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