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人类乳头瘤病毒持续时间及其与复发性宫发育不良的关系

Giorgio Bogani¹, Francesco Sopracordevole², Andrea Ciavattini³

¹Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

|July 4, 2023

概括

人类乳头瘤病毒 (HPV) 在化后长达一年的持久性显著增加了复发性宫发育不良 (CIN2+) 的风险. 然而,HPV持续超过一年似乎不是复发的风险因素.

科学领域:

妇科妇科妇科妇科
在瘤学瘤学.
病毒学病毒学

背景情况:

宫发育不良,特别是高度病变 (CIN2+),通常通过化治疗来管理.
持续的人类乳头瘤病毒 (HPV) 感染是宫癌发展和复发的已知危险因素.
了解HPV持续时间的影响对于完善治疗后监测策略至关重要.

研究的目的:

调查HPV持续时间与经过化后出现复发性高度宫发育不良症 (CIN2+) 的风险之间的关联.
确定与CIN2+复发风险增加相关的HPV持久性的特定时间框架.

主要方法:

一个多机构的意大利数据库的回顾性分析.
纳入标准:患有持续性HPV感染 (≥6个月) 的患者在结婚后.
统计分析:Kaplan-Meier和Cox的比例危险模型来评估CIN2+复发的5年风险.

主要成果:

包括545名患者;29.3%的人具有积极的边际.
6个月的HPV持续性与7.46%的复发风险有关.
12个月的HPV持久性与13.1%的复发风险有很强的相关性.
超过12个月的HPV持久性并没有显著增加复发风险 (HR:1.34).

结论:

HPV持续性是化后CIN2+复发的关键预测因素.
复发的风险随着HPV持续持续长达一年而升级.
持续的HPV感染超过了结合后的第一年似乎不会增加CIN2+复发的风险.

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