在第一个ST段升高心肌梗塞后的心脏重塑中,系统性炎症指数和症状发病时间之间的关系
1Department of Cardiology, Ankara Etlik City Hospital, Ankara, Turkey. a.kivrak89@gmail.com.
Kardiologia polska
|July 4, 2023
概括
系统性炎症反应指数 (SIRI) 可以预测心脏病发作后的不良心脏重塑. 早晨症状发作和较高的SIRI水平与ST升高心肌梗塞 (STEMI) 患者的风险增加有关.
科学领域:
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
背景情况:
- 昼夜节律影响白细胞行为和炎症,影响心肌梗塞 (MI) 后的心脏愈合.
- 了解这些变异对于预测ST升高MI (STEMI) 后的结果至关重要.
研究的目的:
- 研究STEMI患者的新型炎症指数 (SII和SIRI) 和左心室不良改造 (LVAR) 之间的关联.
- 确定症状发作的时间是否影响LVAR风险.
主要方法:
- 对512名首次发生STEMI患者的回顾性分析.
- 症状发作的分类为四个昼夜间隔.
- 在STEMI后6个月评估LVAR.
主要成果:
- 较高的中位数SIRI和系统性免疫炎症 (SII) 指数观察到早晨症状发作 (06:00-11:59).
- 增加的SIRI,早晨症状发作和更高的GRACE分数独立预测了LVAR.
- 与SII相比,SIRI在LVAR预测方面表现出优越的诊断性能.
结论:
- 升高的SIRI是STEMI患者LVAR的独立预测因子,特别是在早晨症状发作时.
- SIRI可以作为一种有价值的查工具,用于识别因LVAR而面临长期心力衰竭风险的STEMI患者.
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