在患有慢性肠道病变的猫身上,便中的急性阶段蛋白质
Dimitra A Karra1, Chris C Chadwick2, Evangelia M Stavroulaki1
1University of Thessaly, Small Animal Clinic, Karditsa, Greece.
Journal of veterinary internal medicine
|July 4, 2023
概括
便α-1-酸-糖蛋白 (AGP) 可能有助于区分猫类小细胞胃肠淋巴瘤 (SCGL) 与炎症性肠病 (IBD) 或食物敏感肠病 (FRE). 便塞鲁洛普拉斯可以监测患有慢性肠病 (CE) 的猫的治疗反应.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 胃肠病学 胃肠病学
- 生物标志物发现发现
背景情况:
- 慢性肠道病变 (CE) 在猫中很普遍,缺乏可靠的生物标志物用于诊断和治疗监测.
- 目前对猫科CE的诊断方法可能是侵入性的和昂贵的.
研究的目的:
- 研究便急性阶段蛋白质作为猫科动物CE的潜在生物标志物.
- 评估这些生物标志物是否能够区分CE亚型,并监测治疗疗效.
主要方法:
- 在28只患有CE (IBD,FRE,SCGL) 的猫和29只健康对照中测量了便中哈普托格洛宾,α-1-酸-糖蛋白 (AGP),胰腺炎相关蛋白-1 (PAP-1),血清素和C-反应蛋白 (CRP) 的度.
- 在治疗前和治疗后使用免疫检测 (饮食,普雷迪尼索隆,ambucil).
主要成果:
- 与对照组相比,患有CE的猫体现出明显较低的便AGP和较高的便Haptoglobin,PAP-1和Ceruloplasmin.
- 便AGP水平在IBD/FRE猫中低于SCGL猫.
- 在CE猫的治疗后,便中塞鲁洛普拉斯的度显著下降.
结论:
- 便AGP显示了在猫中区分SCGL和IBD/FRE的潜力.
- 便塞鲁洛普拉斯可以作为一个客观的标志物来监测猫科动物CE的治疗反应.
相关概念视频
Acute Pancreatitis I: Introduction
410
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
410
Acute Pancreatitis II: Clinical Manifestations and Management
150
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
150


