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在怀孕11-13周时通过母体血清糖化纤维素查先兆子症

N Sokratous¹, M Bednorz¹, P Sarli¹

¹Fetal Medicine Research Institute, King's College Hospital, London, UK.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

|July 4, 2023

概括

母亲因素与血清糖化纤维素 (GlyFn),平均动脉压 (MAP),子宫动脉脉动指数 (UtA-PI) 和胎盘生长因子 (PlGF) 结合,可以改善早期预先 (PE) 检测. 然而,使用这些标志物在怀孕早期查短期PE或妊娠高血压 (GH) 仍然无效.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
生物标志物发现发现

背景情况:

孕前 (PE) 和孕期高血压 (GH) 是重要的妊娠并发症.
早期发现PE对于改善母亲和胎儿的结果至关重要.
第一个三个月的查旨在识别患PE高风险的怀孕.

研究的目的:

评估第一季度查早产和早产前症 (PE) 的有效性.
评估单独和与血清糖化纤维素 (GlyFn),平均动脉压 (MAP),子宫动脉脉动指数 (UtA-PI) 和胎盘生长因子 (PlGF) 结合的母性因素的性能.

主要方法:

一项涉及11-13周怀孕单子妊娠的病例对照研究.
测量了母体血清GlyFn和胎盘生长因子 (PlGF).
记录了平均动脉压 (MAP) 和子宫动脉脉动指数 (UtA-PI).
竞争风险模型被用来结合母亲特征和生物标志物倍数的中位数 (MoM) 值.

主要成果:

将母因子与MAP,UtA-PI和PlGF (三重测试) 结合起来,提高了早产儿前期的检测率 (80%的检测在10%的FPR).
在第一季度使用任何组合的生物标志物对期内PE和妊娠高血压 (GH) 的查表现不佳.
糖化纤维素 (GlyFn) 显示出作为早产前期查生物标志物的潜力.

结论:

糖化纤维素 (GlyFn) 可能是一个有价值的生物标志物,用于第一季度查早产前 (PE).
需要进行前性研究来验证这些发现.
目前使用生物标志物组合的第一季度查方法不足以检测短期PE或妊娠高血压 (GH).

关键词:

竞争风险模型的竞争风险模型第一个三个月的查.平均动脉压力是指动脉的压力.孕产妇产前炎症 (pre-eclampsia) 是一个严重的疾病.生存模型的生存模型.子宫动脉多普勒对象

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