相关实验视频
Updated: Jul 24, 2025

06:09
Breath Collection from Children for Disease Biomarker Discovery
Published on: February 14, 2019
7.0K
美国儿童间歇性和扩散性肺病国家登记:研究设计报告和初始招生队列报告
Rebekah J Nevel1, Gail H Deutsch2, Daniel Craven3
1Department of Child Health, Pediatric Pulmonary Medicine, University of Missouri Children's Hospital, Columbia, Missouri, USA.
Pediatric pulmonology
|July 4, 2023
概括
儿童间歇性和扩散性肺病研究网络 (chILDRN) 登记处收集了683名患有罕见肺病的儿童的数据. 神经内分泌细胞增生是最常见的,观察到大量的氧气使用和无法繁荣.
科学领域:
- 儿科肺病学 儿科肺病学
- 罕见疾病 罕见疾病
- 临床研究 临床研究
背景情况:
- 儿童间歇性和扩散性肺病 (chILD) 是一组罕见的儿科呼吸道疾病.
- 了解CHILD的病因学,表型,自然史和管理对于改善患者的治疗结果至关重要.
- 儿童间歇性和扩散性肺病研究网络 (chILDRN) 启动了一个潜在的注册表,以解决知识差距.
研究的目的:
- 建立一个大,纵向队列的儿童被诊断为间歇性和扩散性肺部疾病.
- 收集全面的临床数据,分析各种chILD亚型的特征和进展.
- 促进合作的研究努力,旨在推进对儿童的理解和治疗.
主要方法:
- 采用了一个纵向的,观察性的,多中心的注册表设计.
- 数据收集发生在美国的25个chILDRN中心,使用单一的机构审查委员会 (IRB) 协议.
- 临床数据通过研究电子数据捕获 (REDCap) 平台进行管理.
主要成果:
- 最初的队列包括683名患有各种ChILD诊断的受试者.
- 婴儿期神经内分泌细胞增生是最常见的诊断 (23%).
- 常见的疾病组件包括间歇性纤维化,免疫失调和呼吸道疾病,补充氧气使用率高 (63%),发育不良 (46%).
结论:
- 儿童登记处代表了美国最大的儿童间歇性和扩散性肺病纵向队列.
- 该注册表为多中心合作提供了一个强大的平台,以加强儿童研究.
- 这些发现强调了与CHILD相关的显著发病率,强调了需要继续调查和改进治疗策略的必要性.
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Study Designs in Epidemiology
280
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
280
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
13
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
13
Observational Studies
8.7K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
8.7K
Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
Chronic Obstructive Pulmonary Disease
1.3K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.3K

