福马公司 (Phoma spp.) 一个尚未开发的细胞毒性化合物的宝藏:当前状态和前景
Mahendra Rai1,2, Beata Zimowska3, Aniket Gade4,5
1Biotechnology Department, Sant Gadge Baba Amravati University, Amravati, 444 602, Maharashtra, India. mahendrarai@sgbau.ac.in.
Applied microbiology and biotechnology
|July 4, 2023
概括
菌产生各种各样的二次代谢物,具有显著的生物活性. 本次审查强调了它们在开发新型抗癌药物的潜力,因为它们具有细胞毒性.
科学领域:
- 菌类学 菌类学是指菌类学.
- 自然产品 化学 化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 马 (Phoma sensu lato) 属被认为可以产生广泛的二次代谢产物.
- 包括P. macrostoma和P. exigua在内的众多Phoma物种是生物活性化合物的来源.
- 这些代谢物表现出各种各样的生物活动,如抗微生物,抗病毒和抗血虫效应.
研究的目的:
- 审查Phoma sensu lato真菌作为生物活性二次代谢物的来源的重要性.
- 为了强调从Phoma物种中获得的二次代谢物的细胞毒性活动.
- 为开发Phoma衍生抗癌剂提供基础.
主要方法:
- 关于Phoma物种及其二次代谢产物的科学出版物的文献综述.
- 报告的二次代谢物的分析,包括现象,cytochalasins和phomapyrone.
- 收集这些代谢物的细胞毒性和抗瘤活性数据.
主要成果:
- 马物种产生了广泛的二次代谢物,具有显著的生物活性.
- 主要化合物如,和细胞素具有显著的细胞毒性.
- 该审查巩固了关于Phoma衍生化合物的细胞毒性潜力的现有知识.
结论:
- 菌是发现新生物活性化合物的宝贵自然资源.
- 已确定的二次代谢产物显示出有前途的细胞毒性和抗瘤活性.
- 本次审查强调了Phoma代谢物在开发新抗癌疗法的潜力.
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