非酒精性脂肪肝疾病作为心力衰竭的新兴风险因素
Riccardo M Inciardi1, Alessandro Mantovani2, Giovanni Targher3
1ASST Spedali Civili Di Brescia, Division of Cardiology and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy.
非酒精性脂肪性肝病 (NAFLD) 与患心力衰竭 (HF) 的风险更高. 晚期肝病,特别是纤维化,加剧了这种风险,需要对患者进行更密切的监测.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪肝 (NAFLD) 和心力衰竭 (HF) 是全球重要的健康问题.
- 观察性研究显示,NAFLD与长期增加新发性HF风险之间存在强烈的关联.
- 即使考虑到常见的心脏代谢风险因素,这种风险仍然存在.
研究的目的:
- 审查NAFLD和新发性HF风险之间的关联.
- 探索潜在的生物机制,将NAFLD和HF联系在一起.
- 总结可能有益于心脏健康的NAFLD的药物治疗方法.
主要方法:
- 这是一个叙事评论.
- 它综合了最近的观察性队列研究的发现.
- 它讨论了潜在的病理生理机制和药物治疗方法.
主要成果:
- 在长期内,NAFLD显著增加了新发性HF的长期风险.
- 晚期肝病和纤维化增加了这种风险.
- 潜在的病理生理机制将NAFLD与HF发展联系起来.
结论:
- 在NAFLD和HF之间存在着强烈的联系,需要加强监测.
- 需要进一步的前性和机制性研究来澄清这种复杂的关系.
- 有针对性的NAFLD药物治疗可能会为心脏带来好处.
更多相关视频
08:35A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
Published on: May 18, 2021
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
相关概念视频
Heart Failure I: Introduction
Pathophysiology of Heart Failure
Heart Failure II: Pathophysiology
Heart Failure IV: Classification and Diagnostic Evaluation
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
