血压变化和动脉硬度之间的时间和双向关联:交叉滞后队列研究
Zhiyuan Wu1,2, Haiping Zhang1, Yutao Wang3
1School of Public Health, Capital Medical University, Beijing, China.
JMIR public health and surveillance
|July 4, 2023
概括
长期血压变化 (BPV) 预测动脉硬,特别是在高血压患者中. 动脉硬似乎不会影响未来的BPV,这表明有单向关系.
科学领域:
- 心血管医学 心血管医学
- 高血压研究 高血压研究
- 生物统计学 生物统计学
背景情况:
- 血压变化 (BPV) 和动脉硬之间的关系尚未完全理解.
- 现有的研究并没有最终确定因果关系或这种关联的方向性.
研究的目的:
- 调查长期BPV和动脉硬之间的时间和双向关联.
- 通过随着时间的推移重复测量,在一个队列中探索这些关系.
主要方法:
- 利用了来自北京健康管理队列的数据,共进行了5次访问 (2010-2019).
- 使用变化系数 (CV) 和标准偏差 (SD) 定义的长期BPV.
- 通过腕脉冲波速度 (baPWV) 测量动脉硬度,并使用交叉滞后和回归模型进行分析.
主要成果:
- 在较早的时间点,BPV显著预测了随后的动脉硬性 (baPWV).
- 动脉硬与随后的BPV之间没有发现显著的关联.
- 这些关联在患有高血压的参与者中更加明显.
结论:
- 长期的BPV是动脉硬的重要预测因素.
- 这种关系似乎是单向的,BPV影响动脉硬.
- 研究结果强调了管理BPV的重要性,特别是在高血压患者.
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