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用托法西提尼布治疗的性结肠炎患者的基线心血管风险主要不良心血管事件:来自OCTAVE临床计划的数据
Stefan Schreiber1, David T Rubin2, Siew C Ng3
1Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel University, Kiel, Germany.
Journal of Crohn's & colitis
|July 4, 2023
概括
治疗性结肠炎的托法西提尼布患者显示,患有先前心血管疾病或较高基线风险的患者更常见的重大心血管不良事件. 个人风险评估对于这些患者的心血管健康管理至关重要.
科学领域:
- 心血管医学 心血管医学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 患有炎症性肠病的患者,包括性结肠炎 (UC),面临着动脉样硬化心血管疾病 (ASCVD) 的风险增加.
- 托法西提尼布是一种口服的Janus激酶抑制剂,用于治疗UC.
- 在用托法西提尼布治疗的UC患者中评估心血管 (CV) 风险很重要.
研究的目的:
- 在UC OCTAVE计划中分析主要不良心血管事件 (MACE).
- 根据患者的基线心血管风险概况来分层MACE率.
主要方法:
- 根据基线CV风险分析MACE的发病率:先前的ASCVD或10年ASCVD风险类别 (低,边界,中等,高).
- 从UC OCTAVE计划中接受托法西提尼布治疗的患者收集了数据.
主要成果:
- 在1157名患者中,4%的患者先前患有ASCVD,而83%的患者具有低边界基线的10年ASCVD风险.
- 八名患者 (0.7%) 经历了MACE;一个人以前有ASCVD.
- 在患有先前ASCVD的患者和具有较高基线10年ASCVD风险的患者中,MACE发病率更高.
结论:
- 在OCTAVE计划中,大多数UC患者的CV风险基线较低.
- 在有ASCVD病史和较高的基线CV风险的患者中,MACE更频繁地发生.
- 建议对接受托法西提尼布治疗的UC患者进行个性化CV风险评估.
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