在最初的攻击中涉及脑干的MOGAD临床特征与NMOSD和MS相比
Qiao Xu1, Xixi Yang1, Zhandong Qiu1
1Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Multiple sclerosis and related disorders
|July 4, 2023
概括
第一次事件中大脑干参与 (BSIFE) 发生在24%的髓寡干细胞糖蛋白抗体相关障碍 (MOGAD) 患者中. MOGAD显示出比AQP4-IgG-NMOSD更好的预后,复发往往发生在脑干中.
科学领域:
- 神经免疫学 神经免疫学
- 神经学 神经学
- 临床神经科学 临床神经科学
背景情况:
- 髓寡核细胞糖蛋白抗体相关疾病 (MOGAD) 是一种炎症性脱髓化疾病.
- 第一次事件中脑干参与 (BSIFE) 是一个重要的临床表现.
- 将MOGAD与AQP4-IgG-NMOSD和MS进行比较,可以了解疾病特征.
研究的目的:
- 为了使MOGAD与BSIFE的特征.
- 为了比较MOGAD-BSIFE与aquaporin-4-IgG血清阳性神经髓炎光学谱障碍 (AQP4-IgG-NMOSD) 和多发性硬化症 (MS).
主要方法:
- 在2017年至2022年期间,确定了MOG-IgG阳性的BSIFE患者.
- 作为对照组,注册了AQP4-IgG-NMOSD和MS患者与BSIFE.
- 分析了病变位置,症状,残疾分数和复发率.
主要成果:
- 在MOGAD患者中,BSIFE发生在24.0%的患者中,其中子,长髓和MCP受影响最多.
- MOGAD患者出现了恶心,吐和打等症状.
- 尽管BSIFE,MOGAD显示出比AQP4-IgG-NMOSD更好的预后,与MS相比,预后没有显著差异.
结论:
- 在MOGAD中,BSIFE是一个值得注意的表现,它影响了特定的大脑干区域.
- MOGAD的预后比AQP4-IgG-NMOSD更为有利.
- 患有BSIFE的MOGAD往往会在脑干中复发,并且在MOG-IgG血清状态转换后会出现一些复发.
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