基于RBP4的多标记得分:急性冠状动脉综合征患者中不良心血管事件的预后工具
Bingqi Ye1, Qian Zhao2,3, Jiahua Fan4
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, and Department of Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou 510000, P.R. China.
视网醇结合蛋白4 (RBP4) 和衍生的多标记得分有效预测急性冠状动脉综合征 (ACS) 患者的主要不良心血管事件 (MACE). 这一分数有助于对二次预防的风险分层.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 临床研究 临床研究
背景情况:
- 视网醇结合蛋白4 (RBP4) 与心血管疾病的进展有关.
- 在急性冠状动脉综合征 (ACS) 患者中,RBP4对于主要心血管不良事件 (MACE) 的预后意义尚未得到充分确立.
研究的目的:
- 为了评估基线RBP4水平的预测值.
- 评估从RBP4获得的新型多标记得分对ACS患者的MACEs的预后效用.
主要方法:
- 一组826名ACS患者被前性跟踪了平均1.95年.
- 血RBP4用酶相关免疫吸收试验量化.
- 开发了5项多标记得分,包括RBP4,左心室喷射分数 (LVEF),N终端亲B型尿素 (NT-proBNP),估计的膜过率 (eGFR) 和年龄.
主要成果:
- 269名ACS患者 (32.57%) 经历了MACE.
- 基于RBP4的多标记得分和MACE风险之间观察到一个显著的分级关联 (例如,与HRadj相关的高得分:3.26;95%CI,2.21-4.81).
- 该得分在各种高风险ACS子组中显示出强大的预后和歧视价值.
结论:
- 来自RBP4的5项评分是风险分层的一个有价值的工具.
- 这一分数可以支持在ACS患者中采取二次预防策略的临床决策.
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