精神分裂症的动态功能性脑皮层失联与抗精神病药物反应相关
Mi Yang1, Liju Liu2, Hongmei Cui3
1The fourth people's hospital of Chengdu, Chengdu, China.
Schizophrenia (Heidelberg, Germany)
|July 4, 2023
概括
精神分裂症 (SCZ) 患者表现出动态功能性脑皮层连接 (dFC) 的改变. 里斯比里治疗使dFC正常化,这表明dFC的变化可能预测SCZ中抗精神病治疗的疗效.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 在精神分裂症 (SCZ) 中记录了thalamocortical网络异常.
- 动态功能连接 (dFC) 和对它的抗精神病作用在SCZ中仍未得到充分研究.
研究的目的:
- 在未使用过药物,首发性SCZ患者中调查dFC.
- 检查12周的RISPERIDONE治疗对thalamocortical dFC的影响.
- 与症状严重程度和治疗反应相关联的dFC变化.
主要方法:
- 招募了以前没有服用过药物的第一期SCZ患者和健康对照组.
- 获得的静止状态fMRI在基线和12周后的RISPERIDONE治疗.
- 使用移动窗口分析来评估六个功能性thalamic分区中的dFC.
主要成果:
- 在SCZ患者中,在thalamic分支中表现出改变的dFC变异.
- 基线VPL-rdSFG dFC与精神病症状相关.
- 里斯佩里治疗降低了VPL-rmoSFG/rdSFG dFC变异,与症状减少相关.
- 在治疗反应者中观察到的VPL-rmoSFG/rdSFG dFC降低.
结论:
- 异常的甲状腺皮层dFC变异性与SCZ中的精神病理有关.
- thalamocortical dFC变异可能作为抗精神病治疗疗效的生物标志物.
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