环境暴露对从未吸烟的患者肺癌的影响
Rahul Chandwani1, Cole Brokamp2,3, Hai Salfity1
1Division of Thoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML-0558, Cincinnati, OH, 45267-0558, USA.
World journal of surgery
|July 4, 2023
概括
像空气污染这样的环境暴露与非吸烟者的肺癌有关. 减少这些暴露可能会改善这个不断增长的患者群体的生存率.
科学领域:
- 环境科学 环境科学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 从未吸烟者中肺癌的发病率正在上升,但环境风险因素仍未得到充分研究.
- 环境空气污染对从不吸烟者肺癌的作用需要进一步调查.
研究的目的:
- 在从未吸烟的患者中调查环境暴露和肺癌之间的关系.
- 确定与非吸烟者肺癌发展和生存相关的特定环境风险因素.
主要方法:
- 分析了前性收集的非小细胞肺癌 (NSCLC) 患者的数据库,这些患者接受了切除 (2006-2021年).
- 使用地理编码的家庭地址估计了环境暴露;采用了后勤回归和生存分析 (Kaplan-Meier,Cox比例危险).
主要成果:
- 在665名NSCLC患者中,67% (10.1%) 是从未吸烟者,表现出不同的特征,如更高的社会经济地位和特定的瘤组织学.
- 与吸烟者相比,从未吸烟者整体生存率有所改善,但癌症复发率相当于吸烟者.
- 细颗粒物,靠近主要道路和绿地与从不吸烟者的整体存活率有显著的关联.
结论:
- 非吸烟肺癌患者具有独特的临床和病理特征,通常与更高的社会经济地位有关.
- 旨在减轻环境暴露的有针对性的干预措施有可能提高这一群体的肺癌存活率.
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