解开NAc D1和D2细胞在享乐饮食中的作用
Mathilde C C Guillaumin1, Paulius Viskaitis1, Eva Bracey1
1Institute for Neuroscience, Institute of Food, Nutrition and Health, Department of Health Sciences and Technology, Swiss Federal Institute of Technology, ETH Zurich, 8603, Schwerzenbach, Switzerland.
Molecular psychiatry
|July 4, 2023
概括
不同的核 (NAc) D1和D2细胞不同调节食物食物.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 分子精神病学分子精神病学
背景情况:
- 过度进食是一种复杂的行为,受到食物的享乐 ('喜欢') 和动机 ('想要') 方面的影响.
- 核 (NAc) 是一个关键的大脑区域,参与奖励处理,但其独特的细胞群体在过度消费中的特定作用尚未完全理解.
研究的目的:
- 研究NAc D1和D2细胞在编码和控制食物奖励的"喜欢"和"想要"组件中的不同作用.
- 为了阐明这些NAc细胞群是如何促进食物选择和过度饮食行为.
主要方法:
- 在小鼠中利用了细胞特异性记录和光遗传学操纵技术.
- 采用行为范式,旨在解开食物奖励和消费的"喜欢"和"想要"方面.
- 检查了NAc D1和D2细胞在食物摄入和选择的各个阶段的活动.
主要成果:
- NAc D2细胞编码了经验依赖的"喜欢",而D1细胞编码了与生俱来的"喜欢"食物.
- D1和D2细胞通过处理食物线索 (D1) 和维持消费持续时间 (D2) 来对"想要"作出不同的贡献.
- D1细胞活动,但不是D2,因果影响了食物偏好,并促进了长期的过度消费.
结论:
- NAc D1和D2细胞在食物奖励和过度进食的神经回路中发挥着互补和不同的作用.
- 这些发现为了解NAc细胞种群如何调解"喜欢"和"想要"来驱动消费行为提供了一个统一的框架.
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