孕前暴露于甲的儿童视力障碍:一项观察性队列研究
R Hamilton1, A Mulvihill2, L Butler3
1Royal Hospital for Children, NHS Greater Glasgow & Clyde and the University of Glasgow, Glasgow, G51 4TF, UK. ruth.hamilton@glasgow.ac.uk.
Eye (London, England)
|July 4, 2023
概括
在子宫内暴露于美沙的儿童在小学年龄时患视力障碍的可能性几乎是两倍. 建议对具有产前阿片类药物暴露史的婴儿进行早期视觉评估.
科学领域:
- 儿科眼科医生 儿科眼科医生
- 新生儿戒断综合征研究研究
- 产前物质暴露研究 产前物质暴露研究
背景情况:
- 接受甲维持治疗 (MMOD) 的母亲生下的孩子可能会面临发展方面的挑战.
- 了解子宫内物质暴露的长期影响对于早期干预至关重要.
研究的目的:
- 为了确定视觉评估失败在8-10岁的孩子出生于MMOD母亲的患病率.
- 为了将这些视觉结果与已记录的子宫内物质暴露相关联.
主要方法:
- 一项观察性队列研究跟踪了暴露于甲和对比儿童.
- 视觉评估评估了敏度,视,眼和立体视觉.
- 统计分析调整了混变量,例如母亲吸烟.
主要成果:
- 暴露于甲的儿童显示出明显更高的视觉"失败"结果的可能性 (调整后的OR为2.6,aRR为1.8).
- 在接受治疗新生儿戒断综合征 (NAS/NOWS) 和未接受治疗的甲暴露儿童之间,没有观察到视觉"失败"率的显著差异.
- 视觉评估的失败包括视敏度下降,眼,眼和立体视力受损.
结论:
- 在产前暴露于美沙的儿童在小学年龄时,明显视力异常的风险增加了近两倍.
- 产前甲暴露应考虑在nystagmus的差异诊断.
- 在入学前推对有产前阿片类药物暴露史的儿童进行例行视觉查.
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