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是否有可能通过使用预防性抗生素来减少牙科植入物失败的发生率?
Carlos Fernando Mourão1, Adam Lowenstein2, Michel Reis Messora3
1Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA, USA. carlos.mourao@tufts.edu.
Evidence-based dentistry
|July 4, 2023
概括
这项随机试验没有发现确的证据表明,克林达米辛可以预防牙植入物失败或并发症. 在健康成年人中,手术前的克林达米辛并没有显著减少早期植入物损失或手术后感染.
科学领域:
- 在口腔外科手术中.
- 临床药理学 临床药理学
背景情况:
- 牙植入程序带有早期失败和手术后并发症的风险.
- 预防性抗生素有时用于减轻这些风险.
研究的目的:
- 评估单次手术前剂量口服克林达米辛在预防早期牙植入物失败和术后并发症方面的疗效.
- 在这种情况下,评估克林达米的安全性.
主要方法:
- 一个随机的,双盲的,安慰剂控制的试验,涉及健康的成年人接受传统的牙植入术.
- 参与者在手术前一小时接受了600毫克口服克林达米辛或安慰剂.
- 监测和分析了包括植入失败,术后感染和不良事件在内的结果.
主要成果:
- 克林达米辛组 (n=31) 发生了两次植入失败,而安慰剂组 (n=31) 没有.
- 报告了三个手术后感染:一个在克林达米辛组,两个在安慰剂组.
- 胃肠道障碍是由克林达米辛组的一名患者报告的.
结论:
- 该研究没有发现确的证据表明,手术前的克林达米辛可以降低健康成年人牙植入物失败或手术后并发症的风险.
- 可能需要进一步的研究来澄清预防性抗生素在牙科植入学中的作用.
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