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与乳腺癌相关的免疫检查点的枢纽基因

Ye Wang^1,2, Yinmei Deng³, Hui Xie^4,5

¹Department of Thoracic Surgery, Affiliated Hospital (Clinical College) of Xiangnan University, Chenzhou, 423000, Hunan Province, People's Republic of China.

Medical oncology (Northwood, London, England)

|July 4, 2023

概括

这项研究确定了CD80和CD276作为关键基因,将二硫化和乳腺癌中的免疫检查点联系起来,为免疫疗法开发提供了新的途径.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

不硫化和免疫检查点基因在癌症治疗中至关重要.
乳腺癌中二硫化和免疫检查点之间的相互作用仍未得到充分研究.

研究的目的:

为了确定关键的枢纽基因连接disulfidptosis和免疫检查点在乳腺癌.
研究这些基因在乳腺瘤发育和预后中的作用.

主要方法:

利用癌症基因组图谱 (TCGA) 数据库来获取乳腺癌表达数据.
构建蛋白质-蛋白质相互作用网络并进行差异表达分析.
采用数学统计和机器学习来识别枢纽基因,然后进行GO和KEGG通路分析.

主要成果:

确定了CD80和CD276作为两个重要的枢纽基因.
在CD80,CD276表达和乳腺瘤发生,进展和患者存活率之间显示出强烈的相关性.
通过差异表达,生存和ROC曲线分析证实了这些基因与乳腺癌发展的关联.

结论:

CD80和CD276是乳腺癌中脱硫化-免疫检查点轴中的关键调节剂.
这些发现为开发针对乳腺癌的向免疫疗法提供了新的视角.
鉴定的枢纽基因为乳腺癌诊断和预后提供了潜在的生物标志物.

关键词:

生物信息学是一种生物信息学.乳腺癌乳腺癌乳腺癌脱硫脱症是一种脱硫脱症.免疫检查站是免疫检查站

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