认知障碍的预测因素:代谢综合征或昼夜综合征
Yang Liu1, Boying Zang2, Jinang Shao1
1Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning Province, China.
BMC geriatrics
|July 4, 2023
概括
代谢综合征和昼夜综合征增加了认知障碍的风险. 单独循环节综合征的风险高于单独的代谢综合征或与循环节综合征相结合的代谢综合征.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 代谢综合征是认知障碍的一个已知的危险因素.
- 循环节律障碍也可能影响认知功能和行为.
- 识别这些风险因素对于早期查和预防认知衰退和痴呆症至关重要.
研究的目的:
- 研究代谢综合征 (MetS) 和昼夜综合征 (CircS) 与认知功能之间的关联.
- 为了确定MetS或CircS,单独或组合,预测认知能力下降.
主要方法:
- 利用多变量通用估计方程 (GEE) 模型来分析认知功能数据.
- 参与者根据基线MetS和CircS的存在进行了分类.
- 认知功能,包括情节性记忆和执行功能,使用经过修改的认知状态电话采访 (TICS) 在4年内进行评估.
主要成果:
- 无论是MetS还是CircS的参与者都显示认知功能显著下降 (β = -0.32).
- 单独患有CircS的个体表现出更明显的认知功能下降 (β = -0.82).
- 单独的MetS并没有显示出与认知能力下降的显著关联 (β = 0.13).
结论:
- 循环节综合征,单独或与代谢综合征结合,与认知障碍的高风险有关.
- 单独CircS和认知障碍之间的关联比MetS和CircS组合的关联更强.
- 循环节综合征可能是比代谢综合征更重要的认知障碍预测因素.
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