瓦伦尼克林和戒烟咨询:一项双盲,随机,并行组,安慰剂对照试验
Pasquale Caponnetto1,2,3, Davide Campagna2,4,5, Jasjit S Ahluwalia6
1Centre for the Prevention and Treatment of Tobacco Addiction (CPCT), University Teaching Hospital "Policlinico-Vittorio Emanuele", University of Catania, Catania, Italy.
与安慰剂相比,当与咨询相结合时,瓦伦尼克林显著提高了戒烟率. 这种药物为寻求戒烟的个人提供了一个有前途的选择.
科学领域:
- 临床研究 临床研究
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 戒烟干预措施的研究不足.
- 瓦雷尼克林在戒除电子烟 (EC) 的有效性和安全性尚未研究.
- 需要严格的研究,以建立旨在戒烟的EC用户的最佳实践.
研究的目的:
- 为了评估瓦雷尼克林的疗效和安全性,并与戒烟戒烟咨询结合使用.
- 评估瓦雷尼克林在专属每日电子烟使用者中有效性的评估,他们打算戒烟.
主要方法:
- 一个双盲,随机,安慰剂对照试验,涉及140名参与者.
- 参与者接受了瓦雷尼克林 (每天两次1毫克) 或安慰剂12周,以及咨询.
- 随访延长至24周,以评估持续戒断率 (CAR) 和点患病率.
主要成果:
- 与安慰剂相比,瓦伦尼克林在4至12周 (40.0%对20.0%) 和4至24周 (34.3%对17.2%) 显著增加了生物化学验证的连续禁欲率 (CAR).
- 在凡尼克林组中,在所有时间点都观察到更高的电子烟戒断率.
- 没有报告与治疗相关的重大严重不良事件.
结论:
- 瓦伦尼克林,当与咨询相结合时,在促进长时间的电子烟戒断方面表现出有效性.
- 这些发现支持使用瓦雷尼克林作为戒烟计划的一部分.
- 该研究为干预效果提供了基准,并可能为未来的卫生当局建议提供信息.
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