Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Social Exchange Theory02:06

Social Exchange Theory

34.6K
We have discussed why we form relationships, what attracts us to others, and different types of love. But what determines whether we are satisfied with and stay in a relationship? One theory that provides an explanation is social exchange theory. According to social exchange theory, we act as naïve economists in keeping a tally of the ratio of costs and benefits of forming and maintaining a relationship with others (Rusbult & Van Lange, 2003).
34.6K
Optimizing Chromatographic Separations01:15

Optimizing Chromatographic Separations

440
Optimizing chromatographic separations is crucial for obtaining clean separations in a minimum amount of time. Optimization is required for several factors, including kinetic effects related to band broadening, plate height, capacity factor, and separation factor.
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
440
Two-Compartment Open Model: Extravascular Administration01:12

Two-Compartment Open Model: Extravascular Administration

242
The two-compartment model for extravascular administration represents a drug's absorption and distribution process. It features a central compartment, where the drug is first absorbed, and a peripheral compartment, which illustrates the drug's distribution throughout the body. The rate of change in drug concentration in the central compartment is calculated by three exponents: absorption, distribution, and elimination.
The absorption exponent (ka) indicates the speed at which the drug...
242
Two-Compartment Open Model: IV Bolus Administration01:18

Two-Compartment Open Model: IV Bolus Administration

580
The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
580
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

5.7K
The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
5.7K
Steady State Concentration01:05

Steady State Concentration

4.5K
A steady state refers to the level of a drug in the body once it has reached an equilibrium between administration and elimination. It represents the point at which the drug administration rate equals the drug elimination rate, resulting in a relatively constant concentration in the body over time. The dynamic equilibrium is crucial to ensure the drug's effectiveness with minimal risk of toxicity.
Most drugs are administered in repeated doses at fixed intervals or through continuous...
4.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Risk factors for asseptic loosening after revision total knee replacement (rTKR): a component-specific analysis of femoral and tibial reconstruction.

The Knee·2026
Same author

Evaluation of dose-response relationships between smoking tobacco, alcohol consumption and oral cancer: a systematic review and meta-analysis.

BMC public health·2026
Same author

The prognostic accuracy of three classification systems used for periprosthetic joint infection : a comparative study of the McPherson, PJI-TNM, and JS-BACH classifications.

The bone & joint journal·2026
Same author

Structure-Property Relationships in Symmetrical Bolaamphiphilic Dehydrodipeptides: Self-Assembled Injectable Hydrogels for Anticancer Drug Delivery.

Gels (Basel, Switzerland)·2026
Same author

Enhanced CCL2-CCR2 signalling promotes recruitment of monocyte-derived macrophages in progressive fibrosing hypersensitivity pneumonitis.

Respiratory research·2026
Same author

Polyarticular Septic Arthritis in an Immunocompromised Adult: A Case Report.

Cureus·2026

相关实验视频

Updated: Jul 24, 2025

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

772

两阶段交换之间的间隔:什么是最佳的,你怎么知道?

Ricardo Sousa1,2, André Carvalho3,4, Daniel Soares3,4

  • 1Department of Orthopedics, Centro Hospitalar Universitário de Santo António, 4099-001, Porto, Portugal. ricardojgsousa@gmail.com.

Arthroplasty (London, England)
|July 4, 2023
PubMed
概括
此摘要是机器生成的。

在周围假肢关节感染 (PJI) 手术后确定重新植入最好的时间是困难的. 目前的测试缺乏准确性,因此决策依赖于临床症状和标记趋势.

关键词:
抗生素假期 抗生素假期混凝土间隔器的吸收方式周围假肢关节感染重新植入的时间表血清学标志物 血清学标志物两个阶段的交换关节管整形.

更多相关视频

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.6K
Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.4K

相关实验视频

Last Updated: Jul 24, 2025

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies
08:24

The Joint Effect of Social Comparison and Social Distance on Evaluation of Intertemporal Choice Outcomes in Event-related Potential Studies

Published on: August 25, 2023

772
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.6K
Measuring Delay Discounting in Humans Using an Adjusting Amount Task
07:47

Measuring Delay Discounting in Humans Using an Adjusting Amount Task

Published on: January 9, 2016

15.4K

科学领域:

  • 整形外科手术 整形外科手术
  • 传染性疾病 传染性疾病
  • 生物标志物 生物标志物

背景情况:

  • 双阶段交换关节整形术是慢性周围假肢关节感染 (PJI) 的常见治疗方法.
  • 准确评估感染根除和最佳的再植入时间仍然具有挑战性.
  • 这些决定的基于证据的指导是有限的.

研究的目的:

  • 批判性地审查有关诊断测试的现有证据,以确定PJI后重新植入的时间.
  • 评估PJI治疗管理中的各种标记物和协议的准确性和实用性.

主要方法:

  • 对现有的科学文献进行批判性审查.
  • 诊断测试的分析,包括血清学,突液分析和培养.
  • 检查最佳时间间隔和抗生素假期协议.

主要成果:

  • 传统的依赖于手术后的正常炎症标志物缺乏预测持续感染的证据.
  • 同胞液培养,分白细胞计数和替代生物标志物在检测感染时具有有限的准确性.
  • 在重新植入之前支持特定时间间隔或为期两周的抗生素假期的证据很少.

结论:

  • 目前,没有明确的指标可以准确地指导PJI病例中再植入的最佳时间.
  • 临床判断,以及趋势的血清和突标志物,对于决策至关重要.