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B Knobling¹, G Franke¹, C Belmar Campos¹

¹Institute for Medical Microbiology, Virology and Hygiene, Department Infection Prevention and Control, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Antimicrobial resistance and infection control

|July 4, 2023

概括

临床分离的抗胺素肠球菌 (VRE) 显示出对UV-C消毒的不同敏感性. 标准的UV-C剂量可能不足以在医院环境中消除高度耐受VRE菌株.

科学领域:

微生物学微生物学
传染性疾病传染性疾病
环境卫生环境卫生

背景情况:

在医院获得的感染构成重大风险.
自动化"无触摸"消毒系统,包括UV-C辐射,用于终端室的清洁.
紫外线对临床病原体与实验室菌株的疗效需要进一步研究.

研究的目的:

分析临床分离的克隆分离的抗胺素耐药肠球菌 (VRE) 对紫外线C辐射的敏感性.
为了比较VRE临床分离物与标准实验室菌株 (Enterococcus hirae ATCC 10541) 的UV-C耐药性.

主要方法:

测试了十个克隆分离的VRE临床分离物和E. hirae ATCC 10541.
污染的陶被照射了50和22mJ/cm2的UV-C剂量,分别在1.0和1.5米的距离上.
辐射后通过培养量化细菌减少.

主要成果:

在VRE菌株之间,UV-C敏感性差异很大,有些菌株比其他菌株耐受性高出十倍.
实验室菌株E. hirae ATCC 10541显示中等敏感性.
与E. hirae ATCC 10541.1.相比,耐受性最强的VRE分离物,特别是ST1283,在22mJ/cm2的水平上显示出明显较低的减少.

结论:

对实验室菌株有效的标准UV-C剂量可能不足以消除耐受性临床VRE隔离物.
未来对自动化紫外线消毒装置的验证应使用最耐受性临床隔离物.
较长的紫外线暴露时间可能是必要的,以确保在现实世界的医院环境中有效消毒.

关键词:

房间自动清除污染自动化消毒消毒消毒消毒紫外线 (UV-C) 是一种紫外线辐射的辐射范科米辛耐药性肠球菌.

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