偶发性骨关节炎病例中的并发症和使用电子健康记录数据匹配的对照
Anne Kamps1, Jos Runhaar2, Maria A J de Ridder3
1Department of General Practice, Erasmus MC, Dr. Molewaterplein 40, 3015 GD, Rotterdam, Netherlands. a.kamps@erasmusmc.nl.
Arthritis research & therapy
|July 4, 2023
概括
新确诊的骨关节炎 (OA) 患者患上许多并发症的几率更高,特别是肌肉骨疾病和肥胖症. 这项研究强调了现有的健康状况与OA发展之间的重要联系.
科学领域:
- 流行病学 流行病学
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
背景情况:
- 在被诊断为骨关节炎 (OA) 的患者中经常观察到并发症.
- 了解先前存在的疾病与OA之间的关联对于患者管理至关重要.
研究的目的:
- 调查一系列先前诊断的并发症与新诊断的关节炎 (OA) 之间的联系.
- 为了比较发生OA病例中的并发症患病率与没有OA的匹配对照.
主要方法:
- 一个用荷兰通用医院的电子健康记录进行的病例控制研究.
- 在2006-2019年期间,通过诊断代码确定了事件OA病例,并与没有OA的对照进行了匹配.
- 为58种并发症计算了几率比率,以评估它们与OA事件的关联.
主要成果:
- 近8万个OA病例与超过31万8000个对照病例进行了匹配.
- 与对照人群相比,OA病例在58种研究的并发症中42种的几率显著更高.
- 肌肉骨疾病和肥胖症与发生的OA有很强的关联.
结论:
- 大多数研究的并发症在发生性OA的患者中更为普遍.
- 这项研究证实了已知的关联,并确定了并发症和OA发展之间的新联系.
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