网状纤维结构在副甲状腺瘤的差异诊断中的作用
Xiumei Hu1, Shurong He2, Xingran Jiang1
1Department of Pathology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
Diagnostic pathology
|July 4, 2023
概括
网状纤维结构 (RFS) 的破坏在非典型的副甲状腺瘤 (APT) 和副甲状腺癌 (PTC) 中比在副甲状腺腺瘤 (PTA) 中更常见. 这一发现表明,RFS的破坏可能表明瘤的不良行为,并有助于诊断.
科学领域:
- 组织病理学 组织病理学
- 在瘤学瘤学.
- 手术病理学手术病理学
背景情况:
- 在甲状腺腺瘤 (PTA),非典型甲状腺瘤 (APT) 和甲状腺癌 (PTC) 中研究网状纤维结构 (RFS).
- 评估RFS特征在区分这些副甲状腺病变的诊断价值.
研究的目的:
- 在PTA,APT和PTC中描述RFS.
- 评估RFS破坏作为甲状腺瘤的诊断指标.
- 为了比较一次性与复发性/转移性PTC中的RFS破坏.
主要方法:
- 从患有PTA,APT和PTC的患者收集了临床数据和病理样本.
- 进行了网状纤维染色,以分析RFS特征.
- 评估了RFS破坏发生率,并将其与临床病理特征相关联.
主要成果:
- RFS破坏发生率:在PTA中为0%,在APT中为44%,在PTC中为86%.
- 对于将PTC与APT区分开来,RFS破坏的灵敏度和特异性分别为81%和56%.
- 在73%的初级PTC和92%的复发性/转移性PTC中观察到RFS破坏.
结论:
- 在甲状腺瘤中,RFS的破坏可能意味着不利的生物行为.
- 网状纤维染色是一种潜在的有价值的工具,可以提高副甲状腺瘤病理学的诊断准确性.
相关概念视频
The Parathyroid Glands
2.2K
The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
2.2K
Fibrous Proteins
2.4K
Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
2.4K
Reticular Dermis
2.6K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.6K


