持续的Helicobacter pylori感染导致快速血葡萄糖水平升高:基于中国非糖尿病人群的回顾性队列研究
Ningning You1, Yi Chen1, Xiaodan Yan1
1Department of Gastroenterology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Zhejiang, China.
Journal of gastroenterology and hepatology
|July 5, 2023
概括
杆菌 (H. pylori) 感染与非糖尿病人的更高的快速血葡萄糖 (FPG) 水平有关. 持续的H. pylori感染可能会增加患糖尿病的风险.
科学领域:
- 胃肠道学和内分泌学
- 代谢健康 代谢健康
- 传染性疾病 传染性疾病
背景情况:
- 在非糖尿病人群中,Helicobacter pylori (H. pylori) 感染和快速血葡萄糖 (FPG) 之间的联系尚不清楚.
- 无论是H. pylori感染还是FPG水平升高,都会给健康带来重大挑战,特别是在中国.
研究的目的:
- 研究非糖尿病人群中H. pylori感染和FPG水平之间的关联.
- 为了确定H. pylori感染是否是FPG升高的独立风险因素.
主要方法:
- 一项回顾性队列研究包括18164名在2017年至2022年期间接受健康检查的个人.
- 通过13C-尿素呼吸试验收集的数据包括血液学指标,身体参数和H. pylori状态.
- 随访间隔超过12个月.
主要成果:
- 在多变量逻辑回归后,H. pylori感染被确定为FPG升高的独立风险因素.
- 持久性H. pylori感染与相比持久性负面或根除的感染群体相比,与显著更高的FPG平均值有关.
- 在3年后,在持久性感染组中观察到高甘油/高密度脂蛋白 (TG/HDL) 的比率升高.
结论:
- 在没有糖尿病的人群中,H. pylori感染是FPG升高的独立风险因素.
- 持续的H. pylori感染有助于增加FPG和TG/HDL水平,可能表明未来糖尿病发病的危险因素.
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