血液性恶性瘤治疗期间的纤维摄入量和补充:一个范围审查
Sarah Andersen1,2, Andrea Henden3,4, Heidi Staudacher5
1Department of Dietetics and Foodservices, Royal Brisbane and Women's Hospital, Herston, QLD, Australia.
概括
在血液癌症治疗期间,饮食纤维摄入量和补充剂可能有利于胃肠道微生物群. 需要进一步的研究来证实它在改善患者结果方面的作用.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 血液癌症治疗显著减少了胃肠道微生物群的多样性,与较差的临床结果相关.
- 识别治疗期间支持微生物群的因素对于改善患者预后至关重要.
研究的目的:
- 对正在接受血液癌症治疗的患者中纤维摄入量和补充剂的现有研究进行范围审查.
- 确定和描述当前关于纤维在关键治疗期间管理胃肠道微生物群中的作用的证据基础.
主要方法:
- 包括关于通常纤维摄入量的观察性研究和关于纤维补充的干预试验.
- 搜索了四个数据库和灰色文献,没有日期限制;仅提供英语语言研究.
- 记录了研究设计,纤维类型 (用于补充试验) 和评估结果.
主要成果:
- 五项研究符合纳入标准:两个观察性试验和三个补充试验.
- 干预性研究在干细胞移植过程中使用单一或组合纤维补充剂 (例如果果-寡糖).
- 评估的关键结果包括补充剂耐受性,临床终点 (感染,GVHD,生存) 和微生物组影响.
结论:
- 目前关于纤维在血液癌症治疗中的作用的研究是有限的,没有确定随机对照试验.
- 需要进一步的研究,特别是通过随机对照试验,以阐明纤维的潜在益处.
- 了解纤维可以改善疾病结果的机制需要进一步的研究.
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