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在模块化多基合成酶中对接域工程及其对结构和功能的影响

Lynn Buyachuihan1, Yue Zhao1, Christian Schelhas1

  • 1Institute of Organic Chemistry and Chemical Biology, Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, 60438 Frankfurt am Main, Germany.

ACS chemical biology
|July 5, 2023
PubMed
概括

使用像SYNZIP和SpyCatcher:SpyTag这样的对接域的模块化多基基合成酶 (PKS) 的蛋白质工程提供了生产化学品的新方法. 然而,模块刚性会影响效率,可以通过增加灵活的链区域来提高效率.

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