由Rhodnius prolixus所发挥的亲BMP功能短胃化揭示了BMP调节器在胚胎模式形成过程中的作用的巨大多样性
M Berni1,2, J Mota1,3, D Bressan1
1Institute for Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Open biology
|July 5, 2023
概括
骨形态遗传通路 (BMP) 信号调节了昆虫的发育. 在Rhodnius prolixus中,BMP控制了整个背腹轴,独特的Sog和Tsg蛋白质有利于BMP信号传递,与其他昆虫不同.
科学领域:
- 发展生物学 发展生物学
- 昆虫遗传学 昆虫遗传学
- 进化生物学 进化生物学
背景情况:
- 双胞胎的背腔腹腔 (DV) 模式主要由骨形态遗传路径 (BMP) 调节.
- 在昆虫中,Toll路径也对DV模式有所贡献,在不同物种中具有不同的重要性.
- 之前的研究表明,在各种昆虫种群中,BMP和Toll通路在DV模式中的作用不同.
研究的目的:
- 为了研究昆虫序列内DV模式的分子控制的保存,Hemiptera.
- 分析BMP和Toll路径在半径动物物种*Rhodnius prolixus*中DV轴形成中的特定作用.
- 了解R. prolixus*发育中的 *短胃流动* (sog) 和 *扭曲胃流动* (tsg) 的功能.
主要方法:
- 对BMP和Toll路径参与DV模式的比较分析.
- 在R. prolixus*中*sog*和*tsg*的基因表达和功能研究.
- 在胚胎发育过程中检查BMP信号梯度.
主要成果:
- 在R. prolixus中的BMP路径决定了整个DV轴,比Toll路径具有更广泛的影响.
- 不同于Oncopeltus fasciatus,R. prolixus,sog和tsg的奥托洛格并没有对抗BMP信号传递,而是促进它.
- 这些发现表明,Sog和TSG蛋白质积极调节BMP信号,以建立R. prolixus*的背部到腹部BMP梯度.
结论:
- 黑类主要依赖于BMP信号来进行DV模式.
- 在修改BMP活性方面,Sog和TSG蛋白的功能在昆虫物种之间具有很大变化,正如它们在R. prolixus中的积极作用所证明的那样.
- 在其他昆虫种群中,如甲虫 (Orthoptera) 和黄虫 (Hymenoptera) 中, *sog* 的消失凸显了 DV 模式的多样化进化策略.
相关概念视频
Cleavage and Blastulation
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
Gastrulation
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...
Determination
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Role of Matrix Metalloproteases in Degradation of ECM
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
A...


