在胆化物尿素和水混合物中,植物醇的相位行为
Saffron J Bryant1, Aaron Elbourne1, Tamar L Greaves1
1School of Science, College of STEM, RMIT University, Melbourne, Australia. Saffron.bryant@rmit.edu.au.
Journal of materials chemistry. B
|July 5, 2023
概括
深度浸泡溶剂 (DES) 能够使脂质自我组合,用于药物输送. 将水添加到胆化物中:尿素DES改变了植物醇的自我组合,产生了可调节的液晶相.
科学领域:
- 材料科学 材料科学 材料科学
- 超分子化学 超分子化学
- 生物医学工程 生物医学工程
背景情况:
- 深度浸泡溶剂 (DES) 是具有可调节性质的多功能非水性溶剂.
- 脂质自我组装成液晶相对于药物输送等应用至关重要.
- 了解DES中的脂质自我组合对于极端温度或对水敏感的应用至关重要.
研究的目的:
- 为了研究在胆化物中植物醇脂的自我组合:urea DES.
- 探索水含量对脂质自我组合和相位行为的影响.
- 评估DES在药物输送中的定制自组装结构的潜力.
主要方法:
- 微角X射线散射 (SAXS) 用于分析结构排序.
- 交叉极化光学显微镜观察相位形成.
- 脂质度的系统变化 (10%和30%重量%) 和DES中的水含量.
主要成果:
- 胆化物:尿素单独支持Pn3m立方相与植物醇.
- 将水添加到 DES 中会诱导一个反向六角形相.
- 水含量调制阶段过渡温度和结构多样性.
结论:
- 胆化物:尿素DES可以支持多种类型的脂质自我组装阶段.
- 水含量是定制基于DES的液晶相的一个关键因素.
- 这为通过添加水来开发触发药物释放系统提供了一条途径.
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