在Ga-DOTATATE扫描上减少的吸收模式可能表明亡,预测染细胞瘤和偏角细胞瘤 (PPGLs) 的攻击性行为
Mechteld Christine de Jong1, Diluka Pinto2, Rajeev Parameswaran2,3
1Division of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Journal of surgical oncology
|July 5, 2023
概括
在Gallium-68 DOTATATE PET/CT扫描中减少的热情可能表明具有侵略性生物学的恶性花色细胞瘤偏瘤 (PPGLs). 考虑FDG-PET/CT在特定患者组进行进一步评估.
科学领域:
- 内分泌学 在内分泌学.
- 核医学就是核医学.
- 在瘤学瘤学.
背景情况:
- 预测色细胞瘤偏瘤 (PPGLs) 的恶性瘤是具有挑战性的.
- 在Ga-DOTATATE PET/CT上减少的嗜好可能表明生物攻击性增加和SSTR表达的改变.
研究的目的:
- 为了调查Ga-DOTATATE PET/CT贪和PPGL中的恶性瘤之间的关联.
- 为了确定恶性PPGLs的临床和分子特征.
主要方法:
- 在2010-2022年期间,对37名为PPGL治疗的患者进行了回顾性队列审查.
- 生物化学,放射学和临床病理学变量的分析,包括Ga-DOTATATE PET/CT发现.
主要成果:
- 37名 (13%) 患者中有5人患有恶性PPGL,平均瘤大小为5.4厘米.
- 恶性PPGLs显示减少了Ga-DOTATATE PET/CT热情 (平均SUVmax4.5) 和高的PASS分数 (平均5.5),通常与缩.
- 患有恶性PPGL的5名患者中有4名患有生殖系SDHB突变;40%发生转移,25%死于并发症.
结论:
- 在DOTATATE扫描中非高度活跃的PPGL可能表明瘤缩和更具侵略性的生物学.
- FDG-PET/CT可能会在患有PPGL的患者的小组中提供额外的诊断信息.
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