婴儿先天性心脏病和支气管炎的吸入药物使用的变化
Namrata Ahuja1,2, Troy Richardson3, Patrick Brady4
1Division of Hospital Medicine, Children's Hospital Los Angeles, Los Angeles, California.
Hospital pediatrics
|July 5, 2023
概括
对于因支气管炎住院治疗的患有先天性心脏病 (CHD) 的婴儿,beta-2激动剂和高血压盐水的医院使用情况有很大差异. 这种药物的使用与这种脆弱人群中改善的临床结果无关.
科学领域:
- 儿科肺病学 儿科肺病学
- 儿童心脏病学 儿童心脏病学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 目前的病毒性支气管炎指南不包括患有先天性心脏病 (CHD) 的婴儿.
- 治疗变异及其对该人群临床结果的影响尚不清楚.
- 这项研究解决了有关心血管疾病和支气管炎的婴儿常见治疗用途的知识差距.
研究的目的:
- 为了评估贝塔-2激动剂和高血压盐水在医院中的使用变化,用于患有冠状动脉疾病的婴儿住院治疗支气管炎.
- 确定这些药物的使用与临床结果之间的医院级关联.
- 为婴儿患有心血管疾病的支气管炎提供基于证据的治疗策略.
主要方法:
- 使用行政数据 (2015-2019) 进行的多中心回顾性队列研究 (2015-2019).
- 包括因支气管炎住院的婴儿 (≤12个月) 与CHD的二次诊断.
- 分析了医院水平的药物使用 (β-2激动剂,高血压盐水) 和与停留时间,再入院,机械通风和ICU利用的关联.
主要成果:
- 鉴定了6846例患有心血管疾病的婴儿因支气管炎住院.
- 在医院使用β-2激动剂 (3.6%-57.4%) 和高血压盐水 (0.0%-65.8%) 中存在显著的差异.
- 药物使用日数与患者结果 (停留时间,再入院,通风,ICU使用) 的比例之间没有发现任何关联.
结论:
- 在患有冠状动脉疾病,因支气管炎住院治疗的婴儿中,在医院使用β-2激动剂和高血压盐水显示出很大的差异.
- 对于这些药物的当前治疗实践在这个人群中与改善的临床结果没有联系.
- 需要进一步的研究,以建立最佳的治疗指南支气管炎在患有心脏病的婴儿.
相关概念视频
Inhaled Medications
319
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
319
Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
Drugs Used in Lower Respiratory Disorders: Overview
500
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
500
COPD: Management Using Bronchodilators and Corticosteroids
250
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
250
Antiasthma Drugs: β2-Adrenoceptor Agonists
314
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
314
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
351
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
351


