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响应刺激的纳米递送系统用于扩大癌症免疫疗法免疫细胞死亡的免疫性细胞死亡

Wenhao Xu^1,2, Wangrui Liu³, Jianfeng Yang⁴

¹Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.

Immunological reviews

|July 5, 2023

概括

响应刺激的纳米粒子通过诱导免疫细胞死亡 (ICD) 来增强癌症免疫疗法. 这些智能纳米输送系统可以改善药物输送,降低毒性,并增强抗瘤免疫力,以获得更好的癌症治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
纳米技术纳米技术
材料科学材料科学材料科学

背景情况:

免疫细胞死亡 (ICD) 通过释放与损伤相关的分子模式和瘤抗原来触发抗瘤免疫反应.
目前的ICD诱导剂面临毒性和瘤局部化不良等挑战,限制了它们的治疗疗效.
基于纳米粒子的药物递送系统提供了一个有希望的策略,以克服癌症免疫治疗中的这些局限性.

研究的目的:

审查刺激响应纳米传递系统的最新进展,以诱导免疫细胞死亡 (ICD).
通过改进ICD诱导来探索这些纳米输送系统在增强癌症免疫疗法的潜力.
讨论在癌症治疗中对刺激响应纳米颗粒的临床转化潜力和未来方向.

主要方法:

对设计用于ICD诱导的刺激响应纳米颗粒的文献综述.
对响应近红外 (NIR) 光,pH,氧化还原潜力或其组合的纳米输送系统的分析.
讨论针对瘤微环境的纳米粒子策略,以加强ICD.

主要成果:

开发多功能纳米粒子,对各种刺激 (NIR,pH,氧化还原) 产生响应,用于向ICD诱导.
使用这些纳米输送系统,证明了提高治疗效率,降低毒性和增强瘤特异性免疫反应.
探索可以被瘤微环境激活的纳米载体,用于精确的药物释放和ICD刺激.

结论:

响应刺激的纳米输送系统通过优化ICD诱导,代表了癌症免疫治疗的重大进步.
这些智能纳米粒子在克服传统ICD诱导器的局限性方面具有很大的前景,从而导致更有效,更安全的癌症治疗.
对ICD生物标志物,免疫抑制微环境和新型纳米输送系统的进一步研究对于加速临床转化和最大限度地提高治疗效益至关重要.

关键词:

免疫性细胞死亡免疫性细胞死亡免疫性免疫性免疫性纳米配送系统系统的纳米配送纳米颗粒是一种纳米粒子.刺激-响应的刺激.瘤微环境是一个微环境.

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